An Epac2 inhibitor
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ESI-05

Item No. 29702

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3,5-trimethyl-2-[(4-methylphenyl)sulfonyl]-benzene
CAS Number
5184-64-5
Synonyms
  • NSC 116966
Molecular Formula
C16H18O2S
Formula Weight
274.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
243 nm
SMILES
CC1=C(S(C2=CC=C(C)C=C2)(=O)=O)C(C)=CC(C)=C1
InChi Code
InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
InChi Key
CGPHOZWFSFNOEQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $169

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    25 mg

    $378

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    Product Description

    ESI-05 is an inhibitor of exchange protein activated by cAMP 2 (Epac2) that inhibits cAMP-induced Epac2 guanine nucleotide exchange factor (GEF) activity with an IC50 value of 0.43 µM in a cell-free assay.1 It is selective for Epac2 over Epac1 and PKA at 25 µM. ESI-05 (1, 5, 10, and 25 µM) reduces activation of the GTPase RAP1 induced by the Epac-selective cAMP analog 007-AM in HEK293 cells expressing Epac2 but has no effect in HEK293 cells expressing Epac1.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsalkova, T., Mei, F.C., Li, S., et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc. Natl. Acad. Sci. USA 109(45), 18613-18618 (2012).