A triterpene with diverse biological activities
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Ganoderic Acid H

Item No. 29703

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12β-(acetyloxy)-3β-hydroxy-7,11,15,23-tetraoxo-lanost-8-en-26-oic acid
CAS Number
98665-19-1
Molecular Formula
C32H44O9
Formula Weight
572.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
255 nm
SMILES
O[C@H]1CCC2(C)C(CC(C(C(C(CC3C(CC(CC(C)C(O)=O)=O)C)=O)(C)C3(C)[C@@H]4OC(C)=O)=C2C4=O)=O)C1(C)C
InChi Code
InChI=1S/C32H44O9/c1-15(11-18(34)12-16(2)28(39)40)19-13-23(37)32(8)24-20(35)14-21-29(4,5)22(36)9-10-30(21,6)25(24)26(38)27(31(19,32)7)41-17(3)33/h15-16,19,21-22,27,36H,9-14H2,1-8H3,(H,39,40)/t15?,16?,19?,21?,22-,27+,30?,31?,32?/m0/s1
InChi Key
YCXUCEXEMJPDRZ-KHWHLGFZSA-N
Origin
Fungus/Ganoderma lucidum
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $204

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    1 mg

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    5 mg

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    Product Description

    Ganoderic acid H is a triterpene that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It inhibits angiotensin-converting enzyme (ACE; IC50 = 26 µM).1 Ganoderic acid H also inhibits HIV-1 protease with an IC50 value of 200 µM.2 It reduces colony formation and migration of MDA-MB-231 breast cancer cells in a concentration-dependent manner.3 In vivo, ganoderic acid H (1, 3, and 5 mg/kg) inhibits acetic acid-induced writhing in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morigiwa, A., Kitabatake, K., Fujimoto, Y., et al. Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum. Chem. Pharm. Bull. (Tokyo) 34(7), 3025-3028 (1986).

    2. El-Mekkawy, S., Meselhy, M.R., Nakamura, N., et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry 49(6), 1651-1657 (1998).

    3. Jiang, J., Grieb, B., Thyagarajan, A., et al. Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-κB signaling. Int. J. Mol. Med. 21(5), 577-584 (2008).

    4. Koyama, K., Imaizumi, T., Akiba, M., et al. Antinociceptive components of Ganoderma lucidum. Planta Med. 63(3), 224-227 (1997).