An MTAP inhibitor
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MT-DADMe-ImmA

Item No. 29711

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylthio)methyl]-3-pyrrolidinol
CAS Number
653592-04-2
Synonyms
  • Methylthio-DADMe-Immucillin A
  • MTDIA
Molecular Formula
C13H19N5OS
Formula Weight
293.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
231, 279 nm
SMILES
NC1=C2C(C(CN3C[C@H](O)[C@@H](CSC)C3)=CN2)=NC=N1
InChi Code
InChI=1S/C13H19N5OS/c1-20-6-9-4-18(5-10(9)19)3-8-2-15-12-11(8)16-7-17-13(12)14/h2,7,9-10,15,19H,3-6H2,1H3,(H2,14,16,17)/t9-,10+/m1/s1
InChi Key
NTHMDFGHOCNNOE-ZJUUUORDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

    $186

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    10 mg

    $332

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    25 mg

    $775

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    Cayman Chemical
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    Product Description

    MT-DADMe-ImmA is an inhibitor of 5'-methylthioadenosine phosphorylase (MTAP; Ki = 1.7 nM).1 It increases levels of MTA (Item No. 15593), a product of polyamine metabolism, in FaDu human squamous cell carcinoma cells when used at a concentration of 1 µM.2 MT-DADMe-ImmA (5, 9, and 21 mg/kg per day for 28 days) reduces tumor growth in a FaDu mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Evans, G.B., Furneaux, R.H., Lenz, D.H., et al. Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J. Med. Chem. 48(14), 4679-4689 (2005).

    2. Basu, I., Cordovano, G., Das, I., et al. A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. The Journal of Biological Chemisty 282(29), 21477-21486 (2007).