An NMDA receptor antagonist
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Radiprodil

Item No. 29712

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,3-dihydro-2-oxo-6-benzoxazolyl)-4-[(4-fluorophenyl)methyl]-α-oxo-1-piperidineacetamide
CAS Number
496054-87-6
Molecular Formula
C21H20FN3O4
Formula Weight
397.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 2mg/mLDMSO: 10mg/mLDMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
λmax
260, 290 nm
SMILES
FC1=CC=C(CC2CCN(C(C(NC3=CC=C(NC(O4)=O)C4=C3)=O)=O)CC2)C=C1
InChi Code
InChI=1S/C21H20FN3O4/c22-15-3-1-13(2-4-15)11-14-7-9-25(10-8-14)20(27)19(26)23-16-5-6-17-18(12-16)29-21(28)24-17/h1-6,12,14H,7-11H2,(H,23,26)(H,24,28)
InChi Key
GKGRZLGAQZPEHO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $120

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    10 mg

    $227

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    25 mg

    $530

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    50 mg

    $882

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    Product Description

    Radiprodil is an antagonist of NR2B subunit-containing NMDA receptors (IC50 = 8 nM).1 It is selective for NR2B subunit-containing NMDA receptors over NR1 and NR2A subunit-containing NMDA receptors at 15 µM. Radiprodil (10 nM) reduces amyloid β (1-42) (Aβ42) and Aβ40-induced decreases in dendritic spine density in mouse hippocampal CA1 pyramidal neurons.2 Radiprodil (2 mg/kg) restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson's disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Barta-Szalai, G., Borza, I., Bozó, E., et al. Oxamides as novel NR2B selective NMDA receptor antagonists. Bioorg. Med. Chem. Lett. 14(15), 3953-3956 (2004).

    2. Rammes, G., Seeser, F., Mattusch, K., et al. The NMDA receptor antagonist radiprodil reverses the synaptotoxic effects of different amyloid-beta (Ab) species on long-term potentiation (LTP). Neuropharmacology 140(10), 184-192 (2018).

    3. Michel, A., Nicolas, J.M., Rose, S., et al. Antiparkinsonian effects of the "Radiprodil and Tozadenant" combination in MPTP-treated marmosets. PLoS One 12(8), e0182887 (2017).