A gp130 inhibitor
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Product Categories

Product Type

Small Molecule Modulators
Small Molecule Inhibitors

Research Area

Cancer

SC144 (hydrochloride)

Item No. 29714

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide, monohydrochloride
CAS Number
917497-70-2
Molecular Formula
C16H11FN6O • HCl
Formula Weight
358.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 5 mg/ml
λmax
269, 314 nm
SMILES
FC1=CC=C2C(N=C(NNC(C3=NC=CN=C3)=O)C4=CC=CN42)=C1.Cl
InChi Code
InChI=1S/C16H11FN6O.ClH/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12;/h1-9H,(H,20,21)(H,22,24);1H
InChi Key
LKFGGXYXFIICED-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    25 mg

    $502

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    Cayman Chemical
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    Product Description

    SC144 is an orally bioavailable gp130 inhibitor.1 It inhibits phosphorylation of STAT1, STAT3, and Akt induced by leukemia inhibitory factor (LIF) and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells when used at a concentration of 20 µM. SC144 induces cell cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines, including prostate, ovarian, lung, breast, and colorectal cancer cells, with IC50 values ranging from 0.4 to 4 µM.2 It reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, S., Grande, F., Garofalo, A., et al. Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol. Cancer Ther. 12(6), 937-949 (2013).

    2. Plasencia, C., Grande, F., Oshima, T., et al. Discovery of a novel quinoxalinhydrazide with a broad-spectrum anticancer activity. Cancer Biol. Ther. 8(5), 458-465 (2009).