A negative allosteric modulator of mGluR5 receptors
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AZD 9272

Item No. 29717

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]-benzonitrile
CAS Number
327056-26-8
Molecular Formula
C14H6F2N4O
Formula Weight
284.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: 50 mMDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
FC1=CC(C#N)=CC(C2=NC(C3=NC=C(F)C=C3)=NO2)=C1
InChi Code
InChI=1S/C14H6F2N4O/c15-10-1-2-12(18-7-10)13-19-14(21-20-13)9-3-8(6-17)4-11(16)5-9/h1-5,7H
InChi Key
RBSPCALDSNXWEP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $117

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    10 mg

    $218

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    25 mg

    $514

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    Product Description

    AZD 9272 is a brain-penetrant negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5; IC50 = 7.6 nM in a FLIPR calcium mobilization assay).1 It is selective for mGluR5 over mGluR1-4 and 6-8 in a FLIPR calcium mobilization assay (IC50s = >30 µM) and a panel of 134 receptors, ion channels, nuclear hormone receptors, transporters, and enzymes at 10 µM in radioligand binding assays.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Raboisson, P., Breitholtz-Emanuelsson, A., Dahllöf, H., et al. Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. Bioorg. Med. Chem. Lett. 22(22), 6974-6979 (2012).