An agonist of GPR35
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YE 120

Item No. 29720

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[3-cyano-5-(3,4-dichlorophenyl)-4,5-dimethyl-2(5H)-furanylidene]-propanedinitrile
CAS Number
383124-82-1
Molecular Formula
C16H9Cl2N3O
Formula Weight
330.2
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
CC1=C(C#N)/C(OC1(C)C2=CC(Cl)=C(Cl)C=C2)=C(C#N)/C#N
InChi Code
InChI=1S/C16H9Cl2N3O/c1-9-12(8-21)15(10(6-19)7-20)22-16(9,2)11-3-4-13(17)14(18)5-11/h3-5H,1-2H3
InChi Key
RSWZFAPYKOARNG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $198

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    Product Description

    YE 120 is an agonist of G protein-coupled receptor 35 (GPR35) with an EC50 value of 32 nM in a dynamic mass redistribution (DMR) assay using HT-29 cells.1 It induces β-arrestin translocation in Tango GPR35-bla U2OS cells (EC50 = 10.2 µM). YE 120 (10 µM) promotes wound closure in YAMC colonic epithelial and IEC-6 intestinal epithelial cell monolayers, an effect that can be blocked by the GPR35 antagonist CID-2745687 (Item No. 12046).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Deng, H., Hu, H., He, M., et al. Discovery of 2-(4-methylfuran-2(5H)-ylidene)malononitrile and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as G protein-coupled receptor 35 (GPR35) agonists. J. Med. Chem. 54(20), 7385-7396 (2011).

    2. Tsukahara, T., Hamouda, N., Utsumi, D., et al. G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells. Pharmacol. Res. 123, 27-39 (2017).