An inhibitor of 17β-HSD3
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TC HSD 21

Item No. 29730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(3-bromo-4-hydroxyphenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone
CAS Number
330203-01-5
Synonyms
  • TC Hydroxysteroid Dehydrogenase 21
Molecular Formula
C17H12BrNO3S2
Formula Weight
422.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mM
SMILES
OC1=CC=C(/C=C2SC(N(C3=CC=C(OC)C=C3)C\2=O)=S)C=C1Br
InChi Code
InChI=1S/C17H12BrNO3S2/c1-22-12-5-3-11(4-6-12)19-16(21)15(24-17(19)23)9-10-2-7-14(20)13(18)8-10/h2-9,20H,1H3/b15-9-
InChi Key
HEFKAUYVLSGPGC-DHDCSXOGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $153

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    Product Description

    TC HSD 21 is an inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3; IC50 = 14 nM in HeLa cells expressing the recombinant human enzyme).1 It is selective for 17β-HSD3 over 17β-HSD1, 17β-HSD2, estrogen receptor α (ERα), the androgen receptor, and the glucocorticoid receptor.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harada, K., Kubo, H., Tanaka, A., et al. Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors. Bioorg. Med. Chem. Lett. 22(1), 504-507 (2012).