A TRPA1 channel agonist
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Product Type

Small Molecule Modulators
Ion Channel Modulators
Activators

Research Area

JT010

Item No. 29732

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)-acetamide
CAS Number
917562-33-5
Molecular Formula
C16H19ClN2O3S
Formula Weight
354.9
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMEthanol: 50 mM
SMILES
ClCC(N(C1=NC(C2=CC=C(OC)C=C2)=CS1)CCCOC)=O
InChi Code
InChI=1S/C16H19ClN2O3S/c1-21-9-3-8-19(15(20)10-17)16-18-14(11-23-16)12-4-6-13(22-2)7-5-12/h4-7,11H,3,8-10H2,1-2H3
InChi Key
KZMAWJRXKGLWGS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $42

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    5 mg

    $103

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    10 mg

    $183

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    Product Description

    JT010 is a transient receptor potential ankyrin 1 (TRPA1) agonist (EC50 = 0.65 nM in a calcium influx assay).1 It is selective for TRPA1 over TRP vanilloid 1 (TRPV1), TRPV3, TRPV4, TRP canonical channel 5 (TRPC5), TRP melastatin 2 (TRPM2), and TRPM8 channels at 1 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takaya, J., Mio, K., Shiraishi, T., et al. A potent and site-selective agonist of TRPA1. J. Am. Chem. Soc. 137(50), 15859-15864 (2015).