An inhibitor of ANO1
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Product Type

Small Molecule Modulators
Ion Channel Modulators
Blockers

Research Area

Ani 9

Item No. 29733

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(4-chloro-2-methylphenoxy)-acetic acid, 2-[(2-methoxyphenyl)methylene]hydrazide
CAS Number
356102-14-2
Molecular Formula
C17H17ClN2O3
Formula Weight
332.8
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/ml
SMILES
ClC1=CC=C(OCC(N/N=C/C2=CC=CC=C2OC)=O)C(C)=C1
InChi Code
InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+
InChi Key
KDALDZRKOBJXIE-VXLYETTFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $120

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    10 mg

    $217

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    Product Description

    Ani 9 is an inhibitor of the calcium-activated chloride channel (CaCC) anoctamin 1 (ANO1) that blocks ATP-induced apical membrane chloride currents in ANO1-expressing Fischer rat thyroid (FRT) cells (IC50 = 77 nM).1 It is selective for ANO1 over ANO2 at 10 μM and the cystic fibrosis transmembrane conductance regulator (CFTR) and epithelial sodium channel (ENaC) at 30 μM. Ani 9 inhibits ATP-induced quenching of a fluorescent intracellular halide sensor in PC3 prostate cancer cells and Capan-1 pancreatic carcinoma cells in a concentration-dependent manner.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seo, Y., Lee, H.K., Park, J., et al. Ani9, A novel potent small-molecule ANO1 inhibitor with negligible effect on ANO2. PLoS One 11(5), e0155771 (2016).