An inhibitor of acid ceramidase
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LCL-521

Item No. 29738

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-glycine, 1,1′-[(1R,2R)-1-(4-nitrophenyl)-2-[(1-oxotetradecyl)amino]-1,3-propanediyl] ester
CAS Number
1226851-11-1
Molecular Formula
C31H52N4O7
Formula Weight
592.8
Purity
≥95%
Formulation
A 10 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMSO: Slightly Soluble: 0.1-1 mg/mlEthanol: Soluble: ≥10 mg/mlPBS (pH 7.2): Slightly Soluble: 0.1-1 mg/ml
SMILES
O=C(CN(C)C)O[C@@H]([C@H](NC(CCCCCCCCCCCCC)=O)COC(CN(C)C)=O)C1=CC=C([N+]([O-])=O)C=C1
InChi Code
InChI=1S/C31H52N4O7/c1-6-7-8-9-10-11-12-13-14-15-16-17-28(36)32-27(24-41-29(37)22-33(2)3)31(42-30(38)23-34(4)5)25-18-20-26(21-19-25)35(39)40/h18-21,27,31H,6-17,22-24H2,1-5H3,(H,32,36)/t27-,31-/m1/s1
InChi Key
ANWWJORIPQKJFW-DLFZDVPBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $123

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    5 mg

    $425

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    10 mg

    $666

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    Product Description

    LCL-521 is an inhibitor of acid ceramidase.1,2 It inhibits acid ceramidase activity in MCF-7 breast cancer cell lysates when used at a concentration of 1 µM.1 LCL-521 (1 and 10 µM) decreases sphingosine levels in MCF-7 cells. It inhibits the proliferation of MCF-7 cells (IC50 = 7.46 µM) and induces cell cycle arrest at the G1 phase when used at a concentration of 2.5 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bai, A., Szulc, Z.M., Bielawski, J., et al. Targeting (cellular) lysosomal acid ceramidase by B13: Design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg. Med. Chem. 22(24), 6933-6944 (2014).

    2. Bai, A., Mao, C., Jenkins, R.W., et al. Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase. PLoS One 12(6), e0177805 (2017).