Betulonic Acid

Betulonic acid is a triterpenoid that has been found in B. chinensis and has diverse biological activities, including antiparasitic, antiviral, and anticancer properties.^1,2,3,4 It is active against the chloroquine-resistant P. falciparum W2 clone (IC₅₀ = 10.01 µM), as well as L. infantum and L. donovani promastigotes when used at a concentration of 50 µM.^3,2 Betulonic acid inhibits replication of herpes simplex virus I (HSV-I), echovirus 6, and the H7N1 strain of influenza A (EC₅₀s = 0.9, 73.32, and 5.7 µM, respectively).⁴ It inhibits proliferation of MGC803, Bcap-37, MCF-7, PC3, and NIH3T3 cancer cells by 68.1, 44.9, 56.1, 52.4, and 22.1%, respectively, when used at a concentration of 20 µM.¹

WARNING This product is not for human or veterinary use.

1. Liu, M., S., Y., Jin, L., et al. Chemical constituents of the ethyl acetate extract of Belamcanda chinensis (L.) DC roots and their antitumor activities. Molecules 17(5), 6156-6169 (2012).

2. L., W., Alakurtti, S., Corral, M.J., et al. Toxicity of betulin derivatives and in vitro effect on promastigotes and amastigotes of Leishmania infantum and L. donovani. J. Antibiot. (Tokyo). 64(7), 475-481 (2011).

3. M.S., d.S., Costa, J.F., Krettli, A.U., et al. Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice. Parasitol. Res. 105(1), 275-279 (2009).

4. Pavlova, N.I., O.V., S., Nikolaeva, S.N., et al. Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses. Fitoterapia. 74(5), 489-492 (2003).