A prodrug form of cilazaprilat
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Active Metabolite(s)
38118Cilazaprilat
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Cilazapril

Item No. 29777

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,9S)-9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
CAS Number
88768-40-5
Synonyms
  • Ro 31-2848
Molecular Formula
C22H31N3O5
Formula Weight
417.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleEthanol: slightly solubleMethanol: slightly soluble
SMILES
O=C(OCC)[C@@H](N[C@@H]1C(N([C@H](C(O)=O)CCC2)N2CCC1)=O)CCC3=CC=CC=C3
InChi Code
InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
InChi Key
HHHKFGXWKKUNCY-FHWLQOOXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

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    10 mg

    $135

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    25 mg

    $294

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    Product Description

    Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat.1 In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Waterfall, J.F. A review of the preclinical cardiovascular pharmacology of cilazapril, a new angiotensin converting enzyme inhibitor. Br. J. Clin. Pharmacol. 27(Suppl 2), 139S-150S (1989).