A synthetic glucocorticoid
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Betamethasone 21-phosphate (sodium salt hydrate)

Item No. 29778

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-fluoro-11β,17-dihydroxy-16β-methyl-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione, disodium salt, hydrate
Molecular Formula
C22H28FO8P • 2Na [XH2O]
Formula Weight
516.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/mlWater: 30 mg/ml
λmax
243 nm
SMILES
O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@H](C)[C@]4(O)C(COP([O-])([O-])=O)=O)=C1.[Na+].[Na+].O
InChi Code
InChI=1S/C22H30FO8P.2Na.H2O/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;;1H2/q;2*+1;/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;;/m0.../s1
InChi Key
FPCPLJJFHIRQGP-ATIGLOHASA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    Product Description

    Betamethasone 21-phosphate is a synthetic glucocorticoid.1 It prevents increases in macrophage and eosinophil numbers in bronchoalveolar lavage fluid (BALF) and decreases in blood leukocyte numbers in a guinea pig model of parainfluenza-3 viral infection when administered at a dose of 8 mg/kg but does not prevent airway hyperresponsiveness after infection.2 Betamethasone 21-phosphate inhibits cell infiltration into the aqueous humor in a rat model of endotoxin-induced uveitis when administered topically or subcutaneously at doses of 0.01-1% or 1 mg/kg, respectively.3 It increases maximal lung pressure volume curves in fetal sheep when administered to pregnant ewes at 0.75 gestation at doses of 80 and 170 µg/kg.1 Betamethasone 21-phosphate increases body weight, impairs learning and memory, increases anxiolytic behavior, and reduces hippocampal neurogenesis in CD-1 mice but reduces body weight and increases neurogenesis with no effect on anxiety in high-anxiety DBA/2 mice when administered at a dose of approximately 25 mg/kg per day in the drinking water for seven weeks.4 Formulations containing betamethasone 12-phosphate and betamethasone acetate have been used in the treatment of severe allergic conditions and a variety of immune-related conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Loehle, M., Schwab, M., Kadner, S., et al. Dose-response effects of betamethasone on maturation of the fetal sheep lung. Am. J. Obstet. Gynecol. 202(2), 186.e181-186.e187 (2010).

    2. Leusink-Muis, A., Ten Broeke, R., Folkerts, G., et al. Betamethasone prevents virus-induced airway inflammation but not airway hyperresponsiveness in guinea pigs. Clin. Exp. Allergy 29(Suppl. 2), 82-85 (1999).

    3. Tsuji, F., Sawa, K., Kato, M., et al. The effects of betamethasone derivatives on endotoxin-induced uveitis in rat. Exp. Eye Res. 64(1), 31-36 (1997).

    4. Aiello, R., Crupi, R., Leo, A., et al. Long-term betamethasone 21-phosphate disodium treatment has distinct effects in CD1 and DBA/2 mice on animal behavior accompanied by opposite effects on neurogenesis. Behav. Brain Res. 278, 155-166 (2015).