An agonist of FPR1 and FPR2
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TC-FPR 43

Item No. 29804

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chlorophenyl)-N′-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea
CAS Number
903895-98-7
Synonyms
  • FPR Agonist 43
Molecular Formula
C20H21ClN4O2
Formula Weight
384.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 1 mg/ml
λmax
247 nm
SMILES
ClC1=CC=C(NC(NC2=C(C(C)C)N(C)N(C3=CC=CC=C3)C2=O)=O)C=C1
InChi Code
InChI=1S/C20H21ClN4O2/c1-13(2)18-17(23-20(27)22-15-11-9-14(21)10-12-15)19(26)25(24(18)3)16-7-5-4-6-8-16/h4-13H,1-3H3,(H2,22,23,27)
InChi Key
PAEBEUZTAPIOIO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    TC-FPR 43 is an agonist of formyl peptide receptor 1 (FPR1) and FPR2, which was previously known as formyl peptide receptor-like 1 (FPRL1).1,2 TC-FPR 43 induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner.2 TC-FPR 43 inhibits migration of polymorphonuclear (PMN) neutrophils induced by fMLP (Item No. 21495) or IL-8 with IC50 values of 0.64 and 0.24 µM, respectively.1 It also reduces ear swelling induced by prostaglandin E2 (PGE2; Item No. 14010) and leukotriene B4 (LTB4; Item No. 20110) in mice when administered at a dose of 50 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bürli, R.W., Xu, H., Zou, X., et al. Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents. Bioorg. Med. Chem. Lett. 16(14), 3713-3718 (2006).

    2. Sogawa, Y., Shimizugawa, A., Ohyama, T., et al. The pyrazolone originally reported to be a formyl peptide receptor (FPR) 2/ALX-selective agonist is instead an FPR1 and FPR2/ALX dual agonist. J. Pharmacol. Sci. 111(3), 317-321 (2009).