A pterin
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7-Biopterin

Item No. 29819

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-7-[(1R,2S)-1,2-dihydroxypropyl]-4(3H)-pteridinone
CAS Number
2636-52-4
Synonyms
  • Primapterin
  • L-Primapterin
Molecular Formula
C9H11N5O3
Formula Weight
237.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
aqueous acid: slightly soluble
λmax
238, 273, 343 nm
SMILES
O=C1N=C(N)N=C2NC([C@@H](O)[C@@H](O)C)=CN=C21
InChi Code
InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-5-7(12-4)13-9(10)14-8(5)17/h2-3,6,15-16H,1H3,(H3,10,12,13,14,17)/t3-,6-/m0/s1
InChi Key
LNXRKRFGNHXANN-DZSWIPIPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $107

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    1 mg

    $203

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    5 mg

    $845

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    10 mg

    $1,267

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    Product Description

    7-Biopterin is a 7-substituted pterin.1 It is formed by non-enzymatic rearrangement of 4a-hydroxy-tetrahydropterin in the absence of pterin-4a-carbinolamine dehydratase (PCD) in vitro and levels are elevated in the urine of hyperphenylalaninemia patients carrying heterozygous mutations in the PCBD gene encoding PCD.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thöny, B., Neuheiser, F., Kierat, L., et al. Hyperphenylalaninemia with high levels of 7-biopterin is associated with mutations in the PCBD gene encoding the bifunctional protein pterin-4a-carbinolamine dehydratase and transcriptional coactivator (DCoH). Am. J. Hum. Genet. 62(6), 1302-1311 (1998).

    2. Curtius, H.C., Kuster, T., Matasovic, A., et al. Primapterin, anapterin, and 6-oxo-primapterin, three new 7-substituted pterins identified in a patient with hyperphenylalaninemia. Biochem. Biophys. Res. Commun. 153(2), 715-721 (1988).