A heterocyclic building block
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5,6-dimethyl-2-Thiouracil

Item No. 29821

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3-dihydro-5,6-dimethyl-2-thioxo-4(1H)-pyrimidinone
CAS Number
28456-54-4
Synonyms
  • Dimethylthiouracil
  • NSC 60687
Molecular Formula
C6H8N2OS
Formula Weight
156.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15mg/mLDMF:PBS (pH 7.2) (1:4): 0.2mg/mLDMSO: 10mg/mL
SMILES
O=C1C(C)=C(C)NC(N1)=S
InChi Code
InChI=1S/C6H8N2OS/c1-3-4(2)7-6(10)8-5(3)9/h1-2H3,(H2,7,8,9,10)
InChi Key
MEAKRQUSGACTFV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $54

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    Cayman Chemical
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    Product Description

    5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones.1 It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Navrotskii, M.B. Synthesis and anti-HIV-1 activity of new 2-[(2-phthalimidoethyl)thio]-4(3H)-pyrimidinone derivatives. Pharm. Chem. J. 39(9), 466-467 (2005).

    2. Schmidt, K.S. In-house validation and factorial effect analysis of a liquid chromatography-tandem mass spectrometry method for the determination of thyreostats in bovine blood plasma. Anal. Bioanal. Chem. 406(3), 735-743 (2014).