An ENPP1 inhibitor
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3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

Item No. 29864

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3′-[(2-chlorophenyl)methylene]bis[4-hydroxy-2H-1-benzopyran-2-one]
CAS Number
4322-58-1
Molecular Formula
C25H15ClO6
Formula Weight
446.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.14 mg/ml
λmax
288, 310 nm
SMILES
OC(C(C=CC=C1)=C1OC2=O)=C2C(C3=CC=CC=C3Cl)C4=C(O)C5=C(C=CC=C5)OC4=O
InChi Code
InChI=1S/C25H15ClO6/c26-16-10-4-1-7-13(16)19(20-22(27)14-8-2-5-11-17(14)31-24(20)29)21-23(28)15-9-3-6-12-18(15)32-25(21)30/h1-12,19,27-28H
InChi Key
XJJPVDONOLMSOS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; Ki = 50 µM).1,2 It also inhibits urease (IC50 = 84.53 µM for the Jack bean enzyme).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities. Bioorg. Med. Chem. 14(23), 8066-8072 (2006).

    2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, and small molecule inhibitors - A STING in the tale of ENPP1. Molecules 24(22), E4192 (2019).

    3. Khan, K.M., Iqbal, S., Lodhi, M.A., et al. Biscoumarin: New class of urease inhibitors; economical synthesis and activity. Bioorg. Med. Chem. 12(8), 1963-1968 (2004).