A bile acid and an FXR agonist
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Isodeoxycholic Acid

Item No. 29890

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β,7α,12α)-7,12-dihydroxy-cholan-24-oic acid
CAS Number
566-17-6
Synonyms
  • 3-deoxyCA
  • 3-deoxy Cholic Acid
  • 3-DCA
  • iDCA
  • isoDCA
  • 7α,12α-Dihydroxycholanic Acid
  • 7α,12α-Dihydroxycholic Acid
Molecular Formula
C24H40O4
Formula Weight
392.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
SMILES
C[C@@]12[C@@](C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCC(O)=O)([H])CCCC1
InChi Code
InChI=1S/C24H40O4/c1-14(7-10-21(27)28)16-8-9-17-22-18(13-20(26)24(16,17)3)23(2)11-5-4-6-15(23)12-19(22)25/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
InChi Key
ZHCAAZIHTDCFJX-QLEQUTGBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Isodeoxycholic acid is a bile acid and an agonist of the farnesoid X receptor (FXR).1 It induces FXR-mediated gene expression in a reporter assay using COS-7 cells when used at a concentration of 30 µM. Isodeoxycholic acid also activates large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rabbit superior mesenteric arteries.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. T., S., Tamehiro, N., Sato, Y., et al. The novel compounds that activate farnesoid X receptor: The diversity of their effects on gene expression. J. Pharmacol. Sci. 107(3), 285-294 (2008).

    2. Dopico, A.M., Walsh, J.V., and Singer, J.J. Natural bile acids and synthetic analogues modulate large conductance Ca2+-activated K+ (BKCa) channel activity in smooth muscle cells. J. Gen. Physiol. 119(3), 251-273 (2002).