A bacterial metabolite and COMT inhibitor
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Methylspinazarin

Item No. 29898

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,5,8-tetrahydroxy-6-methyl-1,4-naphthalenedione
CAS Number
41768-12-1
Synonyms
  • Methylspinazaline
Molecular Formula
C11H8O6
Formula Weight
236.2
Purity
≥95%
Formulation
A solid
SMILES
CC1=CC(O)=C(C(C(O)=C(O)C2=O)=O)C2=C1O
InChi Code
InChI=1S/C11H8O6/c1-3-2-4(12)5-6(7(3)13)9(15)11(17)10(16)8(5)14/h2,12-13,16-17H,1H3
InChi Key
WXLPYHMWBMMBOS-UHFFFAOYSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $250

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    2.5 mg

    $927

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    Product Description

    Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gatechol-O-methyl transerfase inhibitors produced by Streptomyces. J. Antibiot. 26(2), 112-114 (1973).