A sesquiterpenoid
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Isomer(s)
31516Acetoxyvalerenic Acid
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1β-Acetoxypolygodial

Item No. 29901

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,4aS,8R,8aS)-8-(acetyloxy)-1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
CAS Number
1818425-44-3
Molecular Formula
C17H24O4
Formula Weight
292.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
SMILES
CC1(C)CC[C@@H](OC(C)=O)[C@@]2(C)[C@@]1([H])CC=C(C=O)[C@@H]2C=O
InChi Code
InChI=1S/C17H24O4/c1-11(20)21-15-7-8-16(2,3)14-6-5-12(9-18)13(10-19)17(14,15)4/h5,9-10,13-15H,6-8H2,1-4H3/t13-,14-,15+,17+/m0/s1
InChi Key
UKUFQFBUGIRQJW-LJIGWXMPSA-N
Origin
Plant/Tasmannia lanceolata
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $303

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    5 mg

    $902

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    Product Description

    1β-Acetoxypolygodial is a sesquiterpenoid that has been found in T. lanceolata and has antiprotozoal activity.1,2 It is active against T. cruzi amastigotes and trypomastigotes (GI50s = 57.8 and 72 µM, respectively) but not T. cruzi epimastigotes (GI50 = >100 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Deans, R.M., Gardiner, M.G., Horne, J., et al. Isolation and characterization of 1 β‐acetoxypolygodial from Tasmannia lanceolata. Asian J. Chem. 3(11), 1193-1196 (2014).

    2. Turner, D.N., Just, J., Dasari, R., et al. Activity of natural and synthetic polygodial derivatives against Trypanosoma cruzi amastigotes, trypomastigotes and epimastigotes. Nat. Prod. Res. (2019).