An activator of chaperone-mediated autophagy
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QX-77

Item No. 29903

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(7-chloro-2H-1,4-benzoxazin-3-yl)phenyl]-acetamide
CAS Number
1798331-92-6
Molecular Formula
C16H13ClN2O2
Formula Weight
300.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25mg/mLDMF:PBS (pH 7.2) (1:2): 0.3mg/mLDMSO: 15mg/mL
SMILES
ClC1=CC=C(N=C(C2=CC=C(NC(C)=O)C=C2)CO3)C3=C1
InChi Code
InChI=1S/C16H13ClN2O2/c1-10(20)18-13-5-2-11(3-6-13)15-9-21-16-8-12(17)4-7-14(16)19-15/h2-8H,9H2,1H3,(H,18,20)
InChi Key
PYCTUCLCTVWILY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

    $203

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    25 mg

    $477

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    50 mg

    $794

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    Product Description

    QX-77 is an activator of chaperone-mediated autophagy (CMA).1 It decreases mouse embryonic fibroblast (MEF) and Neuro2a cell death induced by paraquat or oleic acid (Item Nos. 90260 | 24659). QX-77 (20 µM) rescues defective trafficking and lysosomal localization of the CMA receptor LAMP2A in Ctns-/- MEFs and CTNS knockout human proximal tubule cells, models of the lysosomal storage disorder cystinosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cuervo, A.M., Gavathiotis, E., Xin, Q., et al. Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof. (2015).

    2. Zhang, J., Johnson, J.L., He, J., et al. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. The Journal of Biological Chemisty 292(25), 10328-10346 (2017).