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SJ000291942 is a bone morphogenic protein (BMP) signaling activator.1 It activates BMP4 in C33A-2D2 human cervical carcinoma clonal reporter cells (EC50 = ≤1 µM). SJ000291942 (0.1-50 µM) induces ventralization, as well as increases expression of the BMP target genes bmp2b and szl and the cooperatively-induced BMP target genes vent and vox in zebrafish embryos. It also induces BMP-dependent osteoblastic differentiation of C2C12 murine myoblasts.
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1. Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway. ACS Chem. Biol. 12(9), 2436-2447 (2017).