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Etodesnitazene (citrate)

Item No. 29916

Restricted Product (Schedule I)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • Desnitroetonitazene
  • Etazene
  • Etazone
Technical Information
Formal Name
2-[(4-ethoxyphenyl)methyl]-N,N-diethyl-1H-benzimidazole-1-ethanamine, 2-hydroxy-1,2,3-propanetricarboxylate
Molecular Formula
C22H29N3O • C6H8O7
Formula Weight
543.6
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
CCN(CC)CCN1C2=CC=CC=C2N=C1CC3=CC=C(OCC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O
InChi Code
InChI=1S/C22H29N3O.C6H8O7/c1-4-24(5-2)15-16-25-21-10-8-7-9-20(21)23-22(25)17-18-11-13-19(14-12-18)26-6-3;7-3(8)1-6(13,5(11)12)2-4(9)10/h7-14H,4-6,15-17H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChi Key
WMZWQRKNBMKEOO-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
I
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Etodesnitazene (citrate) (Item No. 29916) is an analytical reference standard categorized as an opioid.1 Etodesnitazene has been found in parcels seized by law enforcement.2 Etodesnitazene is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).

    2. Siczek, M., Zawadzki, M., Siczek, M., et al. Etazene (N,N‑diethyl‑2‑{[(4‑ethoxyphenyl)methyl]‑1H‑benzimidazol‑1‑yl}‑ethan‑1‑amine (dihydrochloride)): A novel benzimidazole opioid NPS identifed in seized material: Crystal structure and spectroscopic characterization. Forensic Toxicol. 39(1), 146–155 (2021).

    Product Citations

    Robinson, M.J., Chen, L., Thakur, A., et al. Coordinated subpocket engagement underlies nitazene potency at the μ‑opioid receptor. ACS Chem. Neurosci. (2026).

    Truver, M.T., Roman, M., Gomonit, M.M., et al. Fatal intoxications with nitazenes: Postmortem findings, toxicology, and in vitro characterization at the μ-opioid receptor of six nitazene analogues. Arch. Toxicol. (2026).

    Scully, L., Castle, J.W., Di Rago, M., et al. Detection of nitazenes (2-benzylbenzimidazoles)—novel synthetic opioids in coronial casework in Victoria, Australia. Metabolites 16(6), 358 (2026).

    Hataoka, K., Hojo, M., Nomura, S., et al. Evaluation of rewarding effects of nitazene analogs: results from conditioned place preference tests and in vivo microdialysis experiments in mice. J. Toxicol. Sci. 50(1), 33-43 (2025).

    Hardwick, E.K., and Davidson, J.T. Structural characterization of nitazene analogs using electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Drug Test Anal. (2025).

    Kozell, L.B., Eshelman, A., J., Wolfrum, K.M., et al. Pharmacologic characterization of substituted nitazenes at μ, κ, and Δ opioid receptors suggests high potential for toxicity. J. Pharmacol. Exp. Ther. 389(2), 219-228 (2024).

    Taoussi, O., Berardinelli, D., Zaami, S., et al. Human metabolism of four synthetic benzimidazole opioids: Isotonitazene, metonitazene, etodesnitazene, and metodesnitazene. Arch. Toxicol. (2024).

    Vandeputte, M.M., Van Uytfanghe, K., Layle, N.K., et al. Synthesis, chemical characterization, and µ-opioid receptor activity assessment of the emerging group of "nitazene" 2-benzylbenzimidazole synthetic opioids. ACS Chem. Neurosci. 12(7), 1241-1251 (2021).