A naturally occurring peptide agonist of bradykinin B1 receptors
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Lys-(Des-Arg9)-Bradykinin (trifluoroacetate salt)

Item No. 29922

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-9-kallidin, trifluoroacetate
Synonyms
  • (Des-Arg10)-Kallidin
  • (Des-Arg10)-KD
  • KRPPGFSPF-OH
  • Lys-(Des-Arg9)-BK
  • N2-L-lysyl-9-de-L-arginine-Bradykinin
Molecular Formula
C50H73N13O11 • XCF3COOH
Formula Weight
1032.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(N2CCC[C@H]2C(NCC(N[C@H](C(N[C@@H](CO)C(N3CCC[C@H]3C(N[C@H](C(O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)[C@H](CCCCN[H])N[H].OC(C(F)(F)F)=O
InChi Code
InChI=1S/C50H73N13O11.C2HF3O2/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32;3-2(4,5)1(6)7/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55);(H,6,7)/t33-,34-,35-,36-,37-,38-,39-,40-;/m0./s1
InChi Key
BUNFBEBTCVIRNN-HVJIRRSLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $50

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    5 mg

    $125

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    10 mg

    $198

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    25 mg

    $372

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    Product Description

    Lys-(Des-Arg9)-Bradykinin is a naturally occurring peptide agonist of the bradykinin B1 receptor (Ki = 0.12 nM in HEK293 cells expressing the human receptor).1,2 It is selective for bradykinin B1 over B2 receptors (IC50 = >30,000 nM in CHO cells expressing the human receptor).3 Lys-(Des-Arg9)-Bradykinin increases both mRNA and protein levels of the B1 receptor in IMR-90 human lung fibroblasts in a concentration-dependent manner.4 It induces contraction of isolated rabbit aorta (pD2 = 8.6).5 Lys-(Des-Arg9)-Bradykinin decreases blood pressure in LPS-treated rabbits in a dose-dependent manner.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bastian, S., Loillier, B., Paquet, J.L., et al. Stable expression of human kinin B1 receptor in 293 cells: Pharmacological and functional characterization. Br. J. Pharmacol. 122(2), 393-399 (1997).

    2. Drapeau, G., deBlois, D., and Marceau, F. Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. J. Pharmacol. Exp. Ther. 259(3), 997-1003 (1991).

    3. Hess, J.F., Borkowski, J.A., Macneil, T., et al. Differential pharmacology of cloned human and mouse B2 bradykinin receptors. Mol. Pharmacol. 45(1), 1-8 (1994).

    4. Schanstra, J.P., Bataillé, E., Marin Castaño, M.E., et al. The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts. J. Clin. Invest. 101(10), 2080-2091 (1998).

    5. Rhaleb, N.E., Drapeau, G., Dion, S., et al. Structure-activity studies on bradykinin and related peptides: Agonists. Br. J. Pharmacol. 99(3), 445-448 (1990).