A TRPML1 agonist
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ML-SA1

Item No. 29958

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
CAS Number
332382-54-4
Synonyms
  • Mucolipin synthetic agonist 1
Molecular Formula
C22H22N2O3
Formula Weight
362.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
216 nm
SMILES
CC1(C)CC(C)C2=CC=CC=C2N1C(CN3C(C(C=CC=C4)=C4C3=O)=O)=O
InChi Code
InChI=1S/C22H22N2O3/c1-14-12-22(2,3)24(18-11-7-6-8-15(14)18)19(25)13-23-20(26)16-9-4-5-10-17(16)21(23)27/h4-11,14H,12-13H2,1-3H3
InChi Key
KDDHBJICVBONAX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $49

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    50 mg

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    100 mg

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    250 mg

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    Product Description

    ML-SA1 is an agonist of transient receptor potential mucolipin 1 (TRPML1).1 It induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels when used at a concentration of 10 µM. ML-SA1 activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Item No. 20425) prior to isolation from HEK293 cells expressing TRPML1. It also activates whole-endolysosome IML1 in primary murine macrophages.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shen, D., Wang, X., Li, X., et al. Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nat. Commun. 3, 731 (2012).