Phenoxazine

Phenoxazine is a heterocyclic building block.¹ It has been used in the synthesis of phenoxazine derivatives that have anticancer and antimicrobial activities in vitro.^2,3 Phenoxazine has also been used in the synthesis of phenoxazine derivatives used as chromogenic substrates.⁴

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1. Shruti, Dwivedi, J., Kishore, D., et al. Recent advancement in the synthesis of phenoxazine derivatives and their analogues. Synthetic Commun. 48(12), 1377-1402 (2018).

2. Shimizu, S., Suzuki, M., Tomoda, A., et al. Phenoxazine compounds produced by the reactions with bovine hemoglobin show antimicrobial activity against non-tuberculosis mycobacteria. Tohoku J. Exp. Med. 203(1), 47-52 (2004).

3. Che, X.-F., Zheng, C.-L., Akiyama, S.-I., et al. 2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 87(4), 199-213 (2011).

4. Jana, N.C., Patra, M., Brandão, P., et al. Synthesis, structure and diverse coordination chemistry of cobalt(III) complexes derived from a Schiff base ligand and their biomimetic catalytic oxidation of o-aminophenols. Polyhedron 164, 23-34 (2019).