An inhibitor of S1P lyase
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Isomer(s)
33458Imidazole Propionate
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A6770

Item No. 29972

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-ethanone
CAS Number
1331754-16-5
Molecular Formula
C6H8N2O2
Formula Weight
140.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
280 nm
SMILES
OCC1=CN=C(C(C)=O)N1
InChi Code
InChI=1S/C6H8N2O2/c1-4(10)6-7-2-5(3-9)8-6/h2,9H,3H2,1H3,(H,7,8)
InChi Key
JXDVIQLWMKAZBS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $90

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    1 mg

    $168

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    5 mg

    $567

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    10 mg

    $1,042

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    Product Description

    A6770 is an inhibitor of sphingosine-1-phosphate (S1P) lyase.1 It induces accumulation of [3H]sphinganine-1-phosphate ([3H]dhS1P), an S1P lyase substrate, in IT-79MTNC3 cells that endogenously express high levels of S1P lyase (EC50 = <0.01 µM), an effect that is reduced in the presence of vitamin B6 (EC50 = <100 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohtoyo, M., Tamura, M., Machinaga, N., et al. Scintillation proximity assay to detect the changes in cellular dihydrosphingosine 1-phosphate levels. Lipids 51(10), 1207-1216 (2016).