A phenol with diverse biological activities
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Cardol monoene

Item No. 30033

Product Insert (PDF)
Technical Information
Formal Name
5-(8Z)-8-pentadecenyl-1,3-benzenediol
CAS Number
22910-86-7
Synonyms
  • Bilobol
Molecular Formula
C21H34O2
Formula Weight
318.5
Purity
≥95%
Formulation (Request formulation change)
A 5 mg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: Sparingly soluble: 1-10mg/ml
SMILES
OC1=CC(O)=CC(CCCCCCC/C=C\CCCCCC)=C1
InChi Code
InChI=1S/C21H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-16-20(22)18-21(23)17-19/h7-8,16-18,22-23H,2-6,9-15H2,1H3/b8-7-
InChi Key
TUGAUFMQYWZJAB-FPLPWBNLSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $90

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    1 mg

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    5 mg

    $758

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    10 mg

    $1,337

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    Cayman Chemical
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    Product Description

    Cardol monoene is a phenol that has been found in cashew nut shell liquid and has diverse biological activities.1,2,3,4 It inhibits α-glucosidase in a cell-free assay (IC50 = 14.32 nM).2 Cardol (15 µg/ml) inhibits LPS-induced IL-6 and IL-8 production in HepG2 cells.4 It inhibits T. brucei and P. falciparum replication in cell-free assays (EC50s = 0.7 and 12.4 µg/ml, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tyman, J.H., and Kiong, L.S. Long chain phenols: Part XI. Composition of natural cashew nutshell liquid (Anacardium occidentale) from various sources. Lipids 13(8), 525-532 (1978).

    2. He, Q., Ma, P., and Torshizi, R. The impact of some natural phenolic compounds on α-glucosidase and sorbitol dehydrogenase enzymes, and anti-leukemia cancer potential, spin density distributions, and in silico studies. J. Oleo Sci. 71(6), 863-873 (2022).

    3. Siheri, W., Ebiloma, G.U., Igoli, J.O., et al. Isolation of a novel flavanonol and alkylresorcinol with highly potent anti-trypanosomal activity from Libyan propolis. Molecules 24(6), (2019).

    4. Xu, J., Li, Y., Yang, X., et al. Bilobol inhibits the lipopolysaccharide-induced expression and distribution of RhoA in HepG2 human hepatocellular carcinoma cells. Oncol. Lett. 10(2), 962-966 (2015).