A fungal metabolite with anticancer and antimicrobial activities
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Myceliothermophin E

Item No. 30053

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5Z)-1,5-dihydro-5-(2-methylpropylidene)-3-[[(1S,2R,4aR,6R,8aS)-1,2,4a,5,6,7,8,8a-octahydro-3,4a,6-trimethyl-2-[(1E)-1-methyl-1-propen-1-yl]-1-naphthalenyl]carbonyl]-2H-pyrrol-2-one
CAS Number
955083-90-6
Molecular Formula
C26H37NO2
Formula Weight
395.6
Purity
≥70%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble
SMILES
CC1=C[C@]2(C)C[C@H](C)CC[C@@]2([H])[C@H](C(C(C(N/3)=O)=CC3=C\C(C)C)=O)[C@@H]1/C(C)=C/C
InChi Code
InChI=1S/C26H37NO2/c1-8-17(5)22-18(6)14-26(7)13-16(4)9-10-21(26)23(22)24(28)20-12-19(11-15(2)3)27-25(20)29/h8,11-12,14-16,21-23H,9-10,13H2,1-7H3,(H,27,29)/b17-8+,19-11-/t16-,21+,22-,23+,26+/m1/s1
InChi Key
TXVWNUBEANXHMB-FXVWVMPXSA-N
Origin
Fungus/Myceliophthora sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $329

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    Product Description

    Myceliothermophin E is a polyketide-amino acid hybrid fungal metabolite that has been found in T. thermophilus and has anticancer and antimicrobial activities.1,2 It is cytotoxic to DLD-1, Hep3B, HepG2, and HGC-27 cancer cells (IC50s = 0.32, 0.42, 0.26, and 0.08 μg/ml, respectively).1 Myceliothermophin E is active against methicillin-resistant, but not -sensitive, S. aureus (MICs = 15.8 and >100 μM, respectively).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gao, Y.-L., Zhang, M.-L., Wang, X., et al. Isolation and characterization of a new cytotoxic polyketide-amino acid hybrid from Thermothelomyces thermophilus ATCC 42464. Nat. Prod. Res. Epub ahead of print, (2019).

    2. Wang, X., Zhao, L., Liu, C., et al. New tetramic acids comprising of decalin and pyridones from Chaetomium olivaceum SD-80A with antimicrobial activity. Front. Microbiol. 10, 2958 (2020).