An anticoagulant and vitamin K antagonist
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Phenindione

Item No. 30060

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-phenyl-1H-indene-1,3(2H)-dion
CAS Number
83-12-5
Synonyms
  • 2-Phenylindandione
  • 2-Phenyl-1,3-Indandione
  • NSC 41693
  • Phenylindandione
Molecular Formula
C15H10O2
Formula Weight
222.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:40): 0.02 mg/ml
λmax
225, 254 nm
SMILES
O=C1C(C2=CC=CC=C2)C(C3=CC=CC=C31)=O
InChi Code
InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H
InChi Key
NFBAXHOPROOJAW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $81

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    50 mg

    $128

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    100 mg

    $239

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    250 mg

    $553

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    Product Description

    Phenindione is an anticoagulant and vitamin K antagonist.1,2 It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner.1 In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ren, P., Stark, P.Y., Johnson, R.L., et al. Mechanism of action of anticoagulants: correlation between the inhibition of prothrombin synthesis and the regeneration of vitamin K1 from vitamin K1 epoxide. J. Pharmacol. Exp. Ther. 201(3), 541-546 (1977).

    2. Davidson, E.J., Howard, A.N., and Gresham, G.A. The effect of phenindione on rats fed diets which produce thrombosis or experimental atherosclerosis. Br. J. Exp. Pathol. 43(4), 418-423 (1962).