Sanggenone C

Sanggenone C is a flavonoid that has been found in mulberry bark and has diverse biological activities.^1,2,3,4 It inhibits TNF-α- or IL-1β-induced polymorphonuclear leukocyte (PMN) adhesion to human synovial cells (HSCs; IC₅₀s = 27.29 and 54.43 nM, respectively), as well as inhibits NF-κB activation in HSCs.¹ Sanggenone C induces apoptosis and production of reactive oxygen species (ROS) in HT-29 cells when used at concentrations ranging from 10 to 40 µM.² It decreases cell viability of HT-29 cells in vitro and reduces tumor growth in an HT-29 mouse xenograft model when administered at a dose of 10 mg/kg. Sanggenone C increases vertebrate column bone mineralization in a zebrafish model of prednisone-induced osteoporosis.³ It also attenuates cardiac hypertrophy and fibrosis and reduces activation of nuclear factor of activated T cells 2 (NFAT2) in a mouse model of pressure overload-induced cardiac hypertrophy.⁴

WARNING This product is not for human or veterinary use.

1. Li, L.-C., Shen, F., Hou, Q., et al. Inhibitory effect and mechanism of action of sanggenon C on human polymorphonuclear leukocyte adhesion to human synovial cells. Acta Pharmacol. Sin. 23(2), 138-142 (2002).

2. Chen, L.-D., Liu, Z.-H., Zhang, L.-F., et al. Sanggenon C induces apoptosis of colon cancer cells via inhibition of NO production, iNOS expression and ROS activation of the mitochondrial pathway. Oncol. Rep. 38(4), 2123-2131 (2017).

3. Wang, H., Feng, T., Guo, D., et al. Sanggenon C stimulates osteoblastic proliferation and differentiation, inhibits osteoclastic resorption, and ameliorates prednisone-induced osteoporosis in zebrafish model. Molecules 23(9), E2343 (2018).

4. Xiao, L., Gu, Y., Gao, L., et al. Sanggenon C protects against pressure overload‑induced cardiac hypertrophy via the calcineurin/NFAT2 pathway. Mol. Med. Rep. 16(4), 5338-5346 (2017).