A triterpenoid saponin with diverse biological activities
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Polygalasaponin F

Item No. 30064

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2β,3β,4α)-3-(β-D-glucopyranosyloxy)-2,23-dihydroxy-olean-12-en-28-oic acid, O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-β-D-glucopyranosyl ester
CAS Number
882664-74-6
Molecular Formula
C53H86O23
Formula Weight
1091.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15mg/mLDMSO: 25mg/mLDMSO:PBS (pH 7.2) (1:5): 0.16mg/mL
SMILES
OC[C@H]([C@@H](O)[C@H](O)[C@H]1O)O[C@H]1O[C@H]2[C@@H](O)C[C@]3(C)[C@@]4([H])CC=C5[C@]6([H])CC(C)(C)CC[C@]6(C(O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O[C@@H]8O[C@@H](C)[C@H](O[C@@H]9OC[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O)[C@H]8O)=O)CC[C@@]5(C)[C@]4(C)CC[C@@]3([H])[C@]2(C)CO
InChi Code
InChI=1S/C53H86O23/c1-22-40(73-43-37(65)31(59)26(58)20-69-43)36(64)39(67)44(70-22)74-41-35(63)33(61)28(19-55)72-46(41)76-47(68)53-14-12-48(2,3)16-24(53)23-8-9-30-49(4)17-25(57)42(75-45-38(66)34(62)32(60)27(18-54)71-45)50(5,21-56)29(49)10-11-52(30,7)51(23,6)13-15-53/h8,22,24-46,54-67H,9-21H2,1-7H3/t22-,24-,25-,26+,27+,28+,29+,30+,31-,32+,33+,34-,35-,36-,37+,38+,39+,40-,41+,42-,43-,44-,45-,46-,49-,50-,51+,52+,53-/m0/s1
InChi Key
VRDCOPNSCZLBLD-JKVIPCSCSA-N
Origin
Plant/Polygala japonica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $70

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    5 mg

    $303

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    10 mg

    $502

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    25 mg

    $1,003

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    Product Description

    Polygalasaponin F is a triterpenoid saponin originally isolated from Polygala japonica and has diverse biological activities.1,2,3 It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) levels, and nuclear translocation of NF-κB p65 in BV-2 microglia when used at concentrations of 0.1, 1, and 10 μM.1 Polygalasaponin F (0.1, 1, and 10 μM) inhibits rotenone-induced increases in intracellular reactive oxygen species (ROS) levels, decreases in mitochondrial membrane potential, and induction of apoptosis in PC12 cells.2 Intracerebroventricular administration of polygalasaponin F (1 and 10 μM) induces long-term potentiation in the hippocampal dentate gyrus in anesthetized rats, an effect that can be prevented by the NMDA receptor inhibitor MK-801 or the calcium/calmodulin-dependent protein kinase (CaMKII) inhibitor KN-93 (Item Nos. 13319 | 13864 | 21472).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wei, W., Yuan, Y.-H., Gao, Y.-N., et al. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-κB pathway regulation. J. Asian Nat. Prod. Res. 16(8), 865-875 (2014).

    2. Wu, M.-M., Yuan, Y.-H., Chen, J., et al. Polygalasaponin F against rotenone-induced apoptosis in PC12 cells via mitochondria protection pathway. J. Asian Nat. Prod. Res. 16(1), 59-69 (2014).

    3. Sun, F., Sun, J.-D., Han, N., et al. Polygalasaponin F induces long-term potentiation in adult rat hippocampus via NMDA receptor activation. Acta Pharmacol. Sin. 33(4), 431-437 (2012).