A MIF-2 inhibitor
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4-CPPC

Item No. 30068

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(3-carboxyphenyl)-2,5-pyridinedicarboxylic acid
CAS Number
29553-70-6
Molecular Formula
C14H9NO6
Formula Weight
287.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
223 nm
SMILES
OC(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)=O
InChi Code
InChI=1S/C14H9NO6/c16-12(17)8-3-1-2-7(4-8)9-5-11(14(20)21)15-6-10(9)13(18)19/h1-6H,(H,16,17)(H,18,19)(H,20,21)
InChi Key
NBVHLJGGHJLTGM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50 = 27 µM).1 It is selective for MIF-2 over MIF-1 (IC50 = 450 µM). It inhibits MIF-2, but not MIF-1, binding to CD74 in vitro when used at a concentration of 10 µM. 4-CPPC (5, 10, and 25 µM) inhibits MIF-2-induced ERK1/2 phosphorylation in primary human skin fibroblasts.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tilstam, P.V., Pantouris, G., Corman, M., et al. A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity. The Journal of Biological Chemisty 294(49), 18522-18531 (2019).