A local anesthetic
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Product Type

Biochemicals

Research Area

Neuroscience
Pain Research

Pramoxine (hydrochloride)

Item No. 30077

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[3-(4-butoxyphenoxy)propyl]-morpholine, monohydrochloride
CAS Number
637-58-1
Synonyms
  • Pramocaine
Molecular Formula
C17H27NO3 • HCl
Formula Weight
329.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMSO: 5mg/mLEthanol: 15mg/mLEthanol:PBS (pH 7.2) (1:5): 0.16mg/mL
λmax
227 nm
SMILES
CCCCOC1=CC=C(OCCCN2CCOCC2)C=C1.Cl
InChi Code
InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H
InChi Key
SYCBXBCPLUFJID-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $36

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    10 g

    $61

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    25 g

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    50 g

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    Product Description

    Pramoxine is a local anesthetic.1 It reduces electrically induced peak compound action potential (CAP) amplitudes in isolated frog sciatic nerve (IC50 = 0.21 mM).2 Topical administration of pramoxine (0.35 and 0.6%) inhibits winking in a rabbit corneal test, indicating anesthetic activity.1 It inhibits the pinprick-induced cutaneous trunci muscle reflex (CTMR) in the skin of rats (ED50 = 42.1 μmol, s.c.).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmidt, J.L., Blockus, L.E., and Richards, R.K. The pharmacology of pramoxine hydrochloride: A new topical local anesthetic. Curr. Res. Anesth. Analg. 32(6:1), 418-425 (1953).

    2. Hirao, R., Fujita, T., Sakai, A., et al. Compound action potential inhibition produced by various antidepressants in the frog sciatic nerve. Eur. J. Pharmacol. 819, 122-128 (2018).

    3. Chou, A.-K., Chiu, C.-C., Chen, Y.-W., et al. Skin nociceptive block with pramoxine delivery by subcutaneous injection in rats. Pharmacol. Rep. 70(6), 1180-1184 (2018).