An anticholinergic agent
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Product Type

Biochemicals

Diphemanil (methyl sulfate)

Item No. 30090

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(diphenylmethylene)-1,1-dimethyl-piperidinium, methyl sulfate
CAS Number
62-97-5
Synonyms
  • NSC 41725
Molecular Formula
C20H24N • CH3SO4
Formula Weight
389.5
Purity
≥98%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
C[N+]1(C)CC/C(CC1)=C(C2=CC=CC=C2)/C3=CC=CC=C3.[O-]S(=O)(OC)=O
InChi Code
InChI=1S/C20H24N.CH4O4S/c1-21(2)15-13-19(14-16-21)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;1-5-6(2,3)4/h3-12H,13-16H2,1-2H3;1H3,(H,2,3,4)/q+1;/p-1
InChi Key
BREMLQBSKCSNNH-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $75

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    50 mg

    $98

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    100 mg

    $164

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    250 mg

    $369

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    Product Description

    Diphemanil is a quaternary ammonium anticholinergic agent.1 It induces relaxation of isolated guinea pig trachea strips precontracted with methacholine (EC50 = 0.12 nM). Diphemanil reverses increases in lung resistance and decreases in dynamic lung compliance induced by the non-selective acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) in vagotomized cats (ED50s = 17.5 and 19.3 µg/kg, respectively). It reduces salivation induced by the muscarinic acetylcholine receptor agonist pilocarpine in mice when administered subcutaneously at doses ranging from 1.25 to 10 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Diamond, L., and O'Donnell, M. A comparative study of two parasympatholytic bronchodilator agents: Ipratropium bromide and diphemanil methylsulfate. J. Pharmacol. Exp. Ther. 216(1), 1-5 (1981).

    2. Richter, W. Estimation of anticholinergic drug effects in mice by antagonism against pilocarpine-induced salivation. Acta. Pharmacol. Toxicol. (Copenh) 24(2), 243-254 (1966).