An inhibitor of Kv1.3 channels
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PAP-1

Item No. 30105

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-phenoxybutoxy)-7H-furo[3,2-g][1]benzopyran-7-one
CAS Number
870653-45-5
Synonyms
  • 5-(4-Phenoxybutoxy)psoralen
Molecular Formula
C21H18O5
Formula Weight
350.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 9 mg/ml
λmax
221, 249, 268, 309 nm
SMILES
O=C1C=CC(C(OCCCCOC2=CC=CC=C2)=C(C=CO3)C3=C4)=C4O1
InChi Code
InChI=1S/C21H18O5/c22-20-9-8-16-19(26-20)14-18-17(10-13-24-18)21(16)25-12-5-4-11-23-15-6-2-1-3-7-15/h1-3,6-10,13-14H,4-5,11-12H2
InChi Key
KINMYBBFQRSVLL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $44

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    5 mg

    $131

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    10 mg

    $240

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    25 mg

    $542

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    Product Description

    PAP-1 is an inhibitor of Kv1.3 voltage-gated potassium channels (EC50 = 2 nM at -80 mV in cells overexpressing the human channel).1 It is selective for Kv1.3 over a panel of 22 ion channels, including potassium, sodium, calcium, and chloride channels (EC50s = 45-15,000 nM for all). PAP-1 inhibits anti-CD3 antibody-induced proliferation of isolated human CCR7- effector memory T cells. In vivo, PAP-1 (3 mg/kg) inhibits ovalbumin-induced delayed-type hypersensitivity in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schmitz, A., Sankaranarayanan, A., Azam, P., et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol. Pharmacol. 68(5), 1254-1270 (2005).