Schisanhenol

Schisanhenol is a debenzocyclooctene lignan that has been found in Schisandraceae and has diverse biological activities.^1,2,3,4 It completely inhibits iron and cysteine-induced malondialdehyde (MDA) formation in rat liver microsomes when used at a concentration of 1 mM.¹ Schisanhenol reduces HIV-1 viral titers in H9 T cells (EC₅₀ = 5.7 µM).² Schisanhenol is protective against tobacco mosaic virus (TMV) infection in N. glutinosa when applied to leaves at concentrations ranging from 0.15 to 0.5 mM.³ Schisanhenol (10, 30, or 100 mg/kg, i.p.) prevents scopolamine-induced increases in hippocampal MDA and acetylcholinesterase (AChE) levels and decreases hippocampal superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, as well as increases time spent in the target quadrant in the Morris water maze in mice.⁴

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1. Lu, H., and Liu, G.T. Anti-oxidant activity of dibenzocyclooctene lignans isolated from schisandraceae. Planta. Med. 58(4), 311-313 (1992).

2. Chen, M., Kilgore, N., Lee, K.H., et al. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflor. J. Nat. Prod. 69(12), 1697-1701 (2006).

3. Wang, Q.Y., Deng, L.L., Liu, J.J., et al. Schisanhenol derivatives and their biological evaluation against tobacco mosaic virus (TMV). Fitoterapia. 101, 117-124 (2015).

4. Han, Y., Yang, H., Li, L., et al. Schisanhenol improves learning and memory in scopolamine-treated mice by reducing acetylcholinesterase activity and attenuating oxidative damage through SIRT1-PGC-1α-Tau signaling pathway. Int. J. Neurosci. 129(2), 110-118 (2018).