An alkaloid with diverse biological activities
Related Products
Isomer(s)
34457Tuberostemonine
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Neotuberostemonine

Item No. 30116

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,7aR,8R,8aR,11S,11aR,11bS,11cR)-8-ethyldodecahydro-11-methyl-2-[(2S,4S)-tetrahydro-4-methyl-5-oxo-2-furanyl]-furo[2,3-h]pyrrolo[3,2,1-jk][1]benzazepin-10(2H)-one
CAS Number
143120-46-1
Synonyms
  • (+)-Neotuberostemonine
  • Tuberostemonine LG
Molecular Formula
C22H33NO4
Formula Weight
375.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
O=C(O1)[C@@H](C)[C@]2([H])[C@@]1([H])[C@H](CC)[C@]3([H])[C@]4([H])[C@@]2([H])C[C@]([C@@]5([H])OC([C@@H](C)C5)=O)([H])N4CCCC3
InChi Code
InChI=1S/C22H33NO4/c1-4-13-14-7-5-6-8-23-16(17-9-11(2)21(24)26-17)10-15(19(14)23)18-12(3)22(25)27-20(13)18/h11-20H,4-10H2,1-3H3/t11-,12-,13+,14+,15-,16-,17-,18-,19+,20+/m0/s1
InChi Key
GYOGHROCTSEKDY-UEIGSNQUSA-N
Origin
Plant/Stemona japonica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $69

    Add

    5 mg

    $297

    Add

    10 mg

    $525

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Neotuberostemonine is an alkaloid originally isolated from S. tuberosa that has diverse biological activities.1,2,3 It inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at a concentration of 100 µM.1 Neotuberostemonine (50 µM) inhibits RANKL-induced osteoclast differentiation of RAW 264.7 cells.2 It reduces the citric acid-induced cough reflex in conscious guinea pigs when administered at a dose of 133 µmol/kg.3 Neotuberostemonine (40 mg/kg) inhibits pulmonary collagen deposition and fibrosis, as well as bronchoalveolar lavage fluid (BALF) monocyte and lymphocyte infiltration in a mouse model of bleomycin-induced pulmonary fibrosis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xiang, J., Cheng, S., Feng, T., et al. Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages. Int. Immunopharmacol. 36, 158-164 (2016).

    2. Yun, J., Lee, K.Y., and Park, B. Neotuberostemonine inhibits osteoclastogenesis via blockade of NF-kB pathway. Biochimie 157, 81-91 (2019).

    3. Chung, H.-S., Hon, P.-M., Lin, G., et al. Antitussive activity of Stemona alkaloids from Stemona tuberosa. Planta Med. 69(10), 914-920 (2003).