An alkaloid with diverse biological activities
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Dihydrochelerythrine

Item No. 30118

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12,13-dihydro-1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine
CAS Number
6880-91-7
Molecular Formula
C21H19NO4
Formula Weight
349.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
CN1CC2=C(OC)C(OC)=CC=C2C3=C1C4=CC(OCO5)=C5C=C4C=C3
InChi Code
InChI=1S/C21H19NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-9H,10-11H2,1-3H3
InChi Key
ALZAZMCIBRHMFF-UHFFFAOYSA-N
Origin
Plant/Macleaya cordata (Willd.) R. Br.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $52

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    5 mg

    $189

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    10 mg

    $347

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    25 mg

    $556

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    Product Description

    Dihydrochelerythrine is a benzophenanthridine alkaloid that has been found in Bocconia arborea and has diverse biological activities.1,2,3 It is active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all).1 Dihydrochelerythrine inhibits secretion of the hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s = <0.05 μM for both).2 It is cytotoxic to HCT8, BGC-823, and A2780 cancer cells (IC50s = 1.4, 0.4, and 3.5 μM, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Navarro, V., and Delgado, G. Two antimicrobial alkaloids from Bocconia arbore. J. Ethnopharmacol. 66(2), 223-226 (1999).

    2. Wu, Y.R., Ma, Y.B., Zhao, Y.X., et al. Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicol. Planta Med. 73(8), 787-791 (2007).

    3. Deng, A.J., and Qin, H.L. Cytotoxic dihydrobenzophenanthridine alkaloids from the roots of Macleaya microcarp. Phytochemistry 71(7), 816-822 (2010).