A pentapeptide fragment of thymopoietin
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Thymopentin

Item No. 30119

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-lysyl-L-α-aspartyl-L-valyl-L-tyrosine
CAS Number
69558-55-0
Synonyms
  • RKDVY
  • Thymopoietin II (32-36)
  • Thymopoietin Pentapeptide
  • TP5
Molecular Formula
C30H49N9O9
Formula Weight
679.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
226 nm
SMILES
NC(NCCC[C@H](N)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)=O)=O)=O)=N
InChi Code
InChI=1S/C30H49N9O9/c1-16(2)24(28(46)38-22(29(47)48)14-17-8-10-18(40)11-9-17)39-27(45)21(15-23(41)42)37-26(44)20(7-3-4-12-31)36-25(43)19(32)6-5-13-35-30(33)34/h8-11,16,19-22,24,40H,3-7,12-15,31-32H2,1-2H3,(H,36,43)(H,37,44)(H,38,46)(H,39,45)(H,41,42)(H,47,48)(H4,33,34,35)/t19-,20-,21-,22-,24-/m0/s1
InChi Key
PSWFFKRAVBDQEG-YGQNSOCVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $41

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    10 mg

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    25 mg

    $140

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    50 mg

    $255

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    Product Description

    Thymopentin is a pentapeptide fragment of thymopoietin.1 It induces prothymocyte differentiation in isolated mouse splenocytes when used at concentrations ranging from 0.018 to 18 µM. Thymopentin (1 µg/ml) increases proliferation of, and phytohemagglutinin-stimulated IL-2 production in, isolated human peripheral blood lymphocytes (PBLs).2 It reduces the number of splenic autologous rosette-forming cells in athymic mice when administered at doses ranging from 0.02 to 10 mg/kg.1 Adoptive cell transfer of splenocytes isolated from tumor-bearing mice administered thymopentin (100 ng/animal) reduces recipient tumor growth in a murine Lewis lung carcinoma model.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goldstein, G., Scheid, M.P., Boyse, E.A., et al. A synthetic pentapeptide with biological activity characteristic of the thymic hormone thymopoietin. Science 204(4399), 1309-1310 (1979).

    2. Duchateau, J., Servais, G., Cooman, R., et al. In vitro influence of thymopentin on proliferative responses and phytohemagglutinin-induced interleukin 2 production in normal human lymphocyte cultures. Surv. Immunol. Res. 4(1), 116-124 (1985).

    3. Lau, C.Y., Wang, E.Y., and Goldstein, G. Studies of thymopoietin pentapeptide (TP5) on experimental tumors. Cell Immunol. 66(2), 217-232 (1982).