A deoxyribonucleoside
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Alternative(s)
347082'-Deoxycytidine
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2'-Deoxycytidine (hydrochloride)

Item No. 30125

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-cytidine, monohydrochloride
CAS Number
3992-42-5
Synonyms
  • dC
  • NSC 83251
Molecular Formula
C9H13N3O4 • HCl
Formula Weight
263.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 3 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
275 nm
SMILES
OC[C@@H]1[C@@H](O)C[C@@](N2C=CC(N)=NC2=O)([H])O1.Cl
InChi Code
InChI=1S/C9H13N3O4.ClH/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8;/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15);1H/t5-,6+,8+;/m0./s1
InChi Key
LTKCXZGFJFAPLY-OERIEOFYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 g

    $36

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    5 g

    $153

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    Product Description

    2’-Deoxycytidine is a deoxyribonucleoside composed of a deoxyribose sugar and a cytosine base.1 It is phosphorylated by deoxycytidine kinase in the cytosol or thymidine kinase 2 (TK2) in mitochondria to form deoxycytidine monophosphate (dCMP; Item No. 29340).2,3 Oral administration of 2’-deoxycytidine in combination with deoxythymidine delays disease onset and increases lifespan in a Tk2 H126N knock-in (Tk2-/-) mouse model of TK2 deficiency.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Berg, J.M., Tymoczko, J.L., and Stryer, L. Nucleotide biosynthesis. Biochemistry (2002).

    2. Lopez-Gomez, C., Levy, R.J., Sanchez-Quintero, M.J., et al. Deoxycytidine and deoxythymidine treatment for thymidine kinase 2 deficiency. Ann. Neurol. 81(5), 641-652 (2017).

    3. Momparler, R.L., and Fischer, G.A. Mammalian deoxynucleoside kinases. I. Deoxycytidine kinase: Purification, properties, and kinetic studies with cytosine arabinoside. The Journal of Biological Chemisty 243(16), 4298-4304 (1968).