Host: E. coli • AA: 2-130 (full length) • MW: 13.96 kDa
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Citrullinated Histone H2A Type 1 (human, recombinant)

Item No. 30132

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • H2A Clustered Histone 11
  • H2A Histone Family, Member P
  • H2A Type 1
  • H2A.1
  • H2AC11
  • H2AFP
  • HIST1H2AG
  • Histone H2A/ptl
Purity
≥90% estimated by SDS-PAGE
Source
Recombinant human histone H2A type 1 expressed in E. coli, citrullinated with recombinant human PAD4
Amino Acids
2-130 (full length)
MW
13.96 kDa
Formulation (Request formulation change)
Water
UniProt Accession №
P0C0S8
Shipping & Storage Information
Storage
-80°C
Shipping
in continental US; may vary elsewhere
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    100 µg

    $601

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    Product Description

    Citrullinated histone H2A type 1 is a citrullinated form of histone H2A, a core histone and a component of the nucleosome that wraps and condenses DNA.1,2 Histone H2A is subject to citrullination by protein arginine deiminase 4 (PAD4) at the arginine residue at position 3.3 Autoantibodies to histone H2A and citrullinated histone H2A are increased in the plasma of rheumatoid arthritis patients with anti-cyclic citrullinated peptide antibodies (CCP+) but not in the plasma of CCP- patients.1 Cayman’s Citrullinated Histone H2A Type 1 (human, recombinant) protein can be used for Western blot and ELISA applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mergaert, A.M., Bawadekar, M., Nguyen, T.Q., et al. Reduced anti-histone antibodies and increased risk of rheumatoid arthritis associated with a single nucleotide polymorphism in PADI4 in North Americans. Int. J. Mol. Sci. 20(12), E3093 (2019).

    2. Eickbush, T.H., and Moudrianakis, E.N. The histone core complex: An octamer assembled by two sets of protein-protein interactions. Biochemistry 17(23), 4955-4964 (1978).

    3. Fuhrmann, J., and Thompson, P.R. Protein arginine methylation and citrullination in epigenetic regulation. ACS Chem. Biol. 11(3), 654-668 (2016).