Dipyridamole-d₁₆

Dipyridamole-d₁₆ is intended for use as an internal standard for the quantification of dipyridamole (Item No. 18189) by GC- or LC-MS. Dipyridamole is a phosphodiesterase 5A (PDE5A) inhibitor (IC₅₀ = 574 nM) that prevents platelet aggregation by increasing cGMP levels and blocking the reuptake of adenosine via red blood cells.^1,2 It also scavenges the free radicals that inactivate cyclooxygenase, leading to the inhibition of platelet activation and thrombin generation.¹ Dipyridamole has also been shown to inhibit PDE11A with an IC₅₀ value of 370 nM and equilibrative nucleoside transporter 1 (ENT1) with a K_i value of 8.18 nM.^3,4 Formulations containing dipyridamole in combination with aspirin have been used to prevent stroke and other cardiovascular events.

WARNING This product is not for human or veterinary use.

1. Rondina, M.T., and Weyrich, A.S. Targeting phosphodiesterases in anti-platelet therapy. Antiplatelet Agents. Handbook of Experimental Pharmacology 210, 225-238 (2012).

2. Watanabe, N., Adachi, H., Takase, Y., et al. 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5. J. Med. Chem. 43(13), 2523-2529 (2000).

3. Fawcett, L., Baxendale, R., Stacey, P., et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc. Natl. Acad. Sci. USA 97(7), 3702-3707 (2000).

4. Lin, W., and Buolamwini, J.K. Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J. Med. Chem. 50(16), 3906-3920 (2007).