A STING agonist
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MSA-2

Item No. 30140

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
129425-81-6
Synonyms
  • 5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-Butanoic Acid
Molecular Formula
C14H14O5S
Formula Weight
294.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 1 mg/ml
λmax
213, 238, 324 nm
SMILES
COC1=C(OC)C=C(C=C(C(CCC(O)=O)=O)S2)C2=C1
InChi Code
InChI=1S/C14H14O5S/c1-18-10-5-8-6-13(9(15)3-4-14(16)17)20-12(8)7-11(10)19-2/h5-7H,3-4H2,1-2H3,(H,16,17)
InChi Key
APCLRHPWFCQIMG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

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    10 mg

    $169

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    Product Description

    MSA-2 is an agonist of stimulator of interferon genes (STING).1 It binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 μM, respectively) and induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2'3'-cGAMP (Item No. 19887) when used at a concentration of 30 μM. MSA-2 reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression when administered intratumorally or subcutaneously at doses of 450 μg and 50 mg/kg, respectively.2 It also acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Altman, M.D., Cash, B.D., Chang, W., et al. Benzo[B]thiophene compounds as STING agonists. (2018).

    2. Pan, B.-S., Perera, S.A., Piesvaux, J.A., et al. An orally available non-nucleotide STING agonist with antitumor activity. Science 369(6506), eaba6098 (2020).