A peptide with anticancer activity
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Product Categories

Product Type

Biochemicals
Natural Products

Research Area

Cancer
Cell Cycle
G2/M

Dolastatin 15 (trifluoroacetate salt)

Item No. 30144

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-L-valyl-L-valyl-N-methyl-L-valyl-L-prolyl-L-proline, (1S)-1-[[(2S)-2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl]carbonyl]-2-methylpropyl ester, trifluoroacetate salt
Synonyms
  • NSC 617668
Molecular Formula
C45H68N6O9 • XCF3COOH
Formula Weight
837.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: soluble
SMILES
CN(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H](C(C)C)C(N1CCC[C@H]1C(N2[C@H](C(O[C@@H](C(C)C)C(N([C@@H](CC3=CC=CC=C3)C(OC)=C4)C4=O)=O)=O)CCC2)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C45H68N6O9.C2HF3O2/c1-26(2)36(46-40(53)37(27(3)4)47(9)10)42(55)48(11)38(28(5)6)43(56)49-22-16-20-31(49)41(54)50-23-17-21-32(50)45(58)60-39(29(7)8)44(57)51-33(34(59-12)25-35(51)52)24-30-18-14-13-15-19-30;3-2(4,5)1(6)7/h13-15,18-19,25-29,31-33,36-39H,16-17,20-24H2,1-12H3,(H,46,53);(H,6,7)/t31-,32-,33-,36-,37-,38-,39-;/m0./s1
InChi Key
WLQCZJXUPFRLAM-SKKFVSJOSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $281

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    Cayman Chemical
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    Product Description

    Dolastatin 15 is a peptide that has been found in D. auricularia and has anticancer activity.1,2,3 It induces cell cycle arrest at the G2/M phase and inhibits proliferation of JVM-2 and EHEB human B cell leukemia cells when used at a concentration of 1 nM.1 Dolastatin 15 also inhibits proliferation of RPMI-8826, U266, and IM-9 human multiple myeloma cells (IC50s = 0.5-1 nM), as well as a panel of colon and ovarian cancer cell lines (IC50s = 0.031-1.8 nM).2,3 It reduces tumor growth in a CH1 mouse xenograft model when administered at a dose of 5.25 mg/kg per day.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hu, Z.-B., Gignac, S.M., Quentmeier, H., et al. Effects of dolastatins on human b-lymphocytic leukemia cell lines. Leuk. Res. 17(4), 333-339 (1993).

    2. Sato, M., Sagawa, M., Nakazato, T., et al. A natural peptide, dolastatin 15, induces G2/M cell cycle arest and apoptosis of human multiple myeloma cells. Int. J. Oncol. 30(6), 1453-1459 (2007).

    3. Aherne, G.W., Hardcastle, A., Valenti, M., et al. Antitumour evaluation of dolastatins 10 and 15 and their measurement in plasma by radioimmunoassay. Cancer Chemother. Pharmacol. 38(3), 225-232 (1996).