A STING activator
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DSDP

Item No. 30156

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5′aS,10′aS)-1′,5′a,6′,10′a-tetrahydro-dispiro[2H-indene-2,3′-[3H,5H,8H,10H]bisthiazolo[3,4-a:3′,4′-d]pyrazine-8′,2"-[2H]indene]-1,1",3,3",5′,10′-hexone
CAS Number
1777807-64-3
Synonyms
  • ZINC03129319
Molecular Formula
C24H14N2O6S2
Formula Weight
490.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
O=C(C(C=CC=C1)=C1C2=O)C32SC[C@@]4([H])N3C([C@](CSC56C(C(C=CC=C7)=C7C6=O)=O)([H])N5C4=O)=O
InChi Code
InChI=1S/C24H14N2O6S2/c27-17-11-5-1-2-6-12(11)18(28)23(17)25-15(9-33-23)22(32)26-16(21(25)31)10-34-24(26)19(29)13-7-3-4-8-14(13)20(24)30/h1-8,15-16H,9-10H2/t15-,16-/m1/s1
InChi Key
GBYAWPJNMFAKDJ-HZPDHXFCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
    Neutrophil Biology Wall Poster

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    Product Description

    DSDP is an activator of stimulator of interferon genes (STING).1 It induces expression of an IFN-stimulated gene 54 (ISG54) luciferase reporter in HepAD38 cells that constitutively express human cyclic GMP-AMP synthase (cGAS) and STING. DSDP (50 µM) increases IFNB1, TNFA, and IL29 expression in HepG2 cells expressing wild-type human, but not C-terminal truncated human or mouse, STING, as well as in isolated human peripheral blood mononuclear cells (PBMCs). It inhibits yellow fever, dengue, and Zika virus replication in THF fibroblasts at the same concentration.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liu, B., Tang, L., Zhang, X., et al. A cell-based high throughput screening assay for the discovery of cGAS-STING pathway agonists. Antiviral Res. 147, 37-46 (2017).