An inhibitor of LDHA
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NHI 2

Item No. 30201

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-hydroxy-6-phenyl-4-(trifluoromethyl)-1H-indole-2-carboxylic acid, methyl ester
CAS Number
1269802-97-2
Molecular Formula
C17H12F3NO3
Formula Weight
335.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
256, 322 nm
SMILES
ON1C(C(OC)=O)=CC(C1=C2)=C(C(F)(F)F)C=C2C3=CC=CC=C3
InChi Code
InChI=1S/C17H12F3NO3/c1-24-16(22)15-9-12-13(17(18,19)20)7-11(8-14(12)21(15)23)10-5-3-2-4-6-10/h2-9,23H,1H3
InChi Key
YPPFWRWCZNXINO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $135

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    Cayman Chemical
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    Product Description

    NHI 2 is an inhibitor of lactate dehydrogenase A (LDHA; IC50 = 14.7 µM).1 It is selective for LDHA over LDHB (IC50 = 55.8 µM). It inhibits lactate production in HeLa cells when used at concentrations of 100 and 200 µM. NHI 2 is cytotoxic to HeLa cells (IC50 = 33.4 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Granchi, C., Calvaresi, E.C., Tuccinardi, T., et al. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org. Biomol. Chem. 11(38), 6588-6596 (2013).