A product of purine and uric acid metabolism
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Allantoin

Item No. 30204

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2,5-dioxo-4-imidazolidinyl)-urea
CAS Number
97-59-6
Synonyms
  • (±)-Allantoin
  • NSC 7606
  • SD 101
  • 5-Ureidohydantoin
Molecular Formula
C4H6N4O3
Formula Weight
158.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
SMILES
O=C1[C@@H](NC(N)=O)NC(N1)=O
InChi Code
InChI=1S/C4H6N4O3/c5-3(10)6-1-2(9)8-4(11)7-1/h1H,(H3,5,6,10)(H2,7,8,9,11)/t1-/m0/s1
InChi Key
POJWUDADGALRAB-SFOWXEAESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

    $57

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    100 g

    $80

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    Product Description

    Allantoin is a product of purine and uric acid metabolism.1 It is formed through oxidation of uric acid by urate oxidase in most mammals but is formed only through non-enzymatic oxidation by free radicals in humans. Urinary levels of allantoin are increased prior to the onset of Alzheimer’s disease symptoms in mice expressing mutations in amyloid precursor protein and tau (APP/tau) but not during the early/middle stage of the disease, indicating its potential use as a biomarker for predicting Alzheimer’s disease onset.2 Due to the formation of allantoin by free radicals in humans, increased urinary levels are a potential biomarker for oxidative stress status.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martinez-Moral, M.-P., and Kannan, K. Allantoin as a marker of oxidative stress: Inter- and intraindividal variability in urinary concentrations in healthy individuals. Environ. Sci. Technol. Lett. 6, 283-288 (2019).

    2. Fukuhara, K., Ohno, A., Ota, Y., et al. NMR-based metabolomics of urine in a mouse model of Alzheimer’s disease: Identification of oxidative stress biomarkers. J. Clin. Biochem. Nutr. 52(2), 133-138 (2013).