An immunomodulator with diverse biological activities
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Roquinimex

Item No. 30206

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
CAS Number
84088-42-6
Synonyms
  • ABR 212616
  • FCF 89
  • Linomide
  • LS 2616
  • PNU 212616
Molecular Formula
C18H16N2O3
Formula Weight
308.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5mg/mLDMF:PBS (pH 7.2) (1:4): 0.2mg/mLDMSO: 3mg/mLEthanol: 3mg/mL
λmax
232 nm
SMILES
OC(C1=CC=CC=C1N2C)=C(C(N(C)C3=CC=CC=C3)=O)C2=O
InChi Code
InChI=1S/C18H16N2O3/c1-19(12-8-4-3-5-9-12)17(22)15-16(21)13-10-6-7-11-14(13)20(2)18(15)23/h3-11,21H,1-2H3
InChi Key
SGOOQMRIPALTEL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $98

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    10 mg

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    50 mg

    $435

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    100 mg

    $770

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    Product Description

    Roquinimex is an immunomodulator with diverse biological activities.1,2,3,4 In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis.1 It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD).2 Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).3 It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ilbäck, N.G., Fohlman, J., Slorach, S., et al. Effects of the immunomodulator LS 2616 on lymphocyte subpopulations in murine coxsackievirus B3 myocarditis. J. Immunol. 142(9), 3225-3228 (1989).

    2. Xiao, Z.-Y., Zhou, W.-X., Zhang, Y.-X., et al. Roquinimex-mediated protection effect on the development of chronic graft-versus-host disease in mice is associated with induction of Th1 cytokine production and inhibition of proinflammatory cytokine production. Life Sci. 81(19-20), 1403-1410 (2007).

    3. Liu, Q., Wang, Y., Wan, M.X., et al. Roquinimex inhibits dextran sodium sulfate-induced murine colitis. Inflamm. Res. 52(2), 64-68 (2003).

    4. Gross, D.J., Reibstein, I., Weiss, L., et al. The antiangiogenic agent linomide inhibits the growth rate of Von Hippel-Lindau paraganglioma xenografts to mice. Clin. Cancer Res. 5(11), 3669-3675 (1999).